🔬 Product Description
Afatinib is an irreversible ErbB family of blockers that suppress information transmission and block the major pathways involved in cancer cell growth and division. Because ErbB family information transduction mechanism can be triggered by multiple homodimers and heterodimers, simultaneous inhibition of multiple ErbB family members (such as EGFR, HER2, ErbB3 and ErbB4) can effectively interrupt the downstream information transduction.
| Product Name |
Details |
| Appearance | White Powder |
| Specification | 99% |
| Shelf Life | 2 years when properly stored |
💊 Function and Application
Afatinib is a drug approved for the treatment of non-small cell lung carcinoma (NSCLC). It acts as a potent angiokinase inhibitor. Like lapatinib and neratinib, afatinib is a tyrosine kinase inhibitor (TKI) that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and EGFR kinases.
Afatinib is not only active against EGFR mutations targeted by first-generation TKIs like erlotinib or gefitinib, but also against those not sensitive to these standard therapies. Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2-driven cancers.
❓ Frequently Asked Questions
Q1: What is Afatinib primarily used for?
Afatinib is an approved treatment for non-small cell lung carcinoma (NSCLC) and acts as an irreversible ErbB family blocker.
Q2: What is the purity level of your Afatinib powder?
Our Afatinib powder maintains a high purity level of over 99%.
Q3: How does Afatinib differ from first-generation TKIs?
Unlike first-generation TKIs, Afatinib irreversibly inhibits multiple members of the ErbB family (EGFR, HER2, ErbB3, ErbB4) and is effective against mutations that may be resistant to standard therapies.
Q4: What are the available packaging options?
The standard transport packaging is a 1kg Foil Bag or a 25kg Drum, with a minimum order quantity (MOQ) of 1kg.
Q5: What is the shelf life and storage condition?
Afatinib has a shelf life of 2 years when stored properly in a cool, dry place away from direct sunlight.
Q6: Are samples available for quality testing?
Yes, samples are available upon request to ensure the product meets your specifications.
SJ medical
