Basic Information
Certification
GMP, HSE, ISO 9001, USP, BP
Suitable for
Elderly, Adult
Appearance
White to off-White Powder
Grade
Pharmaceutical Grade
Product Description
Ceritinib is a white to off-white solid crystalline powder with a molecular weight of 558.14 g/mol. It is practically insoluble in water but soluble in organic solvents such as dimethyl sulfoxide and ethanol. Identification is performed by infrared spectroscopy (IR) and high-performance liquid chromatography (HPLC). Purity is determined by HPLC with a specification of not less than 98.5%. Related substances are strictly controlled with individual impurities not exceeding 0.3%.
Product Details
| Product Name | Ceritinib |
| Appearance | White Powder |
| CAS | 1032900-25-6 |
| MF | C28H36ClN5O3S |
| MW | 558.13514 |
Application & Function
Ceritinib is a potent and selective oral inhibitor of anaplastic lymphoma kinase (ALK), a tyrosine kinase receptor involved in the pathogenesis of certain cancers. It functions by competitively binding to the ATP-binding site of ALK, thereby inhibiting its kinase activity and downstream signaling pathways including STAT3, AKT, and ERK. Ceritinib is particularly effective against non-small cell lung cancer (NSCLC) harboring ALK rearrangements. It also exhibits inhibitory activity against other kinases including IGF-1R, ROS1, and InsR.
Technical Specification
Frequently Asked Questions
What is the purity of your Ceritinib powder?
Our Ceritinib powder maintains a high purity level of over 99%, tested and verified via HPLC methods.
What certifications does this product hold?
The product is manufactured under GMP, HSE, ISO 9001 standards and complies with USP and BP grade specifications.
How should Ceritinib powder be stored?
It should be stored in a cool, dry place away from direct sunlight. The shelf life is 2 years when stored properly.
What is the primary application of this material?
It is primarily used as a pharmaceutical raw material for research and production of targeted anti-cancer treatments, specifically for ALK-positive conditions.
Is the powder soluble in water?
No, Ceritinib is practically insoluble in water but shows good solubility in organic solvents like DMSO and ethanol.
SJ medical
