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Niclosamide Bolus is an anthelmintic containing Niclosamide B.P. Vet, active against tapeworms and intestinal flukes such as paramphistomum in ruminants.
This product is a tapeworm killing drug. It has good expelling effect on the naked head tapeworm, leafy naked head tapeworm and dwarf paranaked head tapeworm of horses. It is effective against monitz tapeworm, Taenia solium and striped tapeworm of cattle and sheep, and has the same effect on the scolex and somite of tapeworm. It is effective against Taenia solium canis, Taenia pisiformis, Taenia solium and Taenia solium in dogs and cats, but poor against Echinococcus granulosus in dogs. It can drive and kill Taenia solium and Taenia infundibulum of birds. It also has the function of killing snail, Schistosoma cercaria and miracidia.
The mechanism of action of this product is that it inhibits the absorption of glucose by tapeworms, uncouples the oxidative phosphorylation process in the mitochondria of tapeworms, blocks the tricarboxylic acid cycle, leads to the accumulation of lactic acid, and kills tapeworms. The anthelmintic effect of niclosamide may also be related to its over stimulation of ATPase activity in mitochondria. The damage degree of Taenia solium was related to the time of drug action.
This product is rarely absorbed from the gastrointestinal tract after oral administration and maintains a high concentration in the intestine. A small amount of absorbed offspring will be metabolized into inactive niclosamide metabolites, which are mainly excreted from feces.
